| Pick | Round | Player | Position | High School Team | MLB Team |
| 11 | 1st | Grayson Rodriguez | RHP | Central Heights | Baltimore |
| 12 | 1st | Jordan Groshans | 3B | Magnolia | Toronto |
| 48 | 2nd | Simeon Woods-Richardson | RHP | Ft. Bend Kempner | New York Mets |
| 51 | 2nd | Braxton Ashcraft | RHP | Robinson | Pittsburgh |
| 88 | 3rd | Adam Kloffenstein | RHP | Magnolia | Toronto |
| 95 | 3rd | Mateo Gil | SS | Keller Timber Creek | St. Louis |
| 119 | 4th | Mason Englert | RHP | Forney | Texas |
| 134 | 4th | Braydon Fisher | RHP | Clear Falls | Los Angeles Dodgers |
| 433 | 14th | Korey Holland | OF | Langham Creek | Cleveland |
| 452 | 15th | Milan Walla | OF | Kerrville Tivy | Kansas City |
| 529 | 18th | Alberto Gonzalez | RHP | Laredo Alexander | Cincinnati |
| 610 | 20th | Kason Howell | OF | Liberty Christian | Boston |
| 827 | 28th | Jonathan Jones | RHP | Manvel | Philadelphia |
| 857 | 29th | Jaylen Smith | LHP | Copperas Cove | Philadelphia |
| 861 | 29th | William Duncan | RHP | Richardson | San Diego |
| 1000 | 33rd | Adrian Torres | OF | El Paso Americas | Boston |
| 1022 | 34th | Ty Madden | RHP | Cy Ranch | Kansas City |
| 1091 | 36th | Bo Blessie | RHP | Midland Lee | Washington |
| 1093 | 36th | Jose Gutierrez | C | Arlington Lamar | Cleveland |
| 1122 | 37th | Antonio Cruz | OF | Bellaire Episcopal | Houston Astros |
| 1152 | 38th | Cole Stilwell | C | Rockwall Heath | Houston Astros |
| 1154 | 38th | Connery Peters | RHP | Joshua | Los Angeles Dodgers |
| 1158 | 39th | Mason Montgomery | LHP | Leander | Chicago White Sox |
| 1182 | 39th | Brandon Birdsell | RHP | Willis | Houston Astros |
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